Publications
Pre-Print
SIGNAL-seq: Multimodal Single-cell Inter- and Intra-cellular Signalling Analysis
J.W. Opzoomer, R. O’Sullivan*, J. Sufi*, R.R. Madsen, X. Qin, E. Basiarz, C.J. Tape
bioRxiv (2024)Oncogenic PIK3CA Corrupts Growth Factor Signaling Specificity
R.R. Madsen, A. Le Marois, O. Mruk, M. Voliotis, S. Yin, J. Sufi, X. Qin, S.J. Zhao, J. Gorczynska, D. Morelli, L. Davidson, E. Sahai, V.I. Korolchuk, C.J. Tape, B. Vanhaesebroeck
bioRxiv (2023)OPS-γδ: Allogeneic Opsonin-secreting γδT Cell Immunotherapy for Solid Tumours Mediates Direct and Bystander Immunity
D. Fowler, M. Barisa, A.S. Navarrete, C. Nattress, E. Hawkins, E. Vassalou, A. Kanouta, J. Counsell, E.M. Rota, P. Vlckova, B. Draper, C.J. Tape, K. Chester, J. Anderson, J. Fisher
bioRxiv (2022)
Peer-Reviewed
Functional Analysis of Cell Plasticity Using Single-cell Technologies
X. Qin, C.J. Tape
Trends in Cell Biology (2024)An Oncogenic Phenoscape of Colonic Stem Cell Polarisation
X. Qin*, F.C. Rodriguez*, J. Sufi, P. Vlckova, J. Claus, C.J. Tape
Cell (2023)Trellis Tree-based Analysis Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses
M.R. Zapatero*, A. Tong*, J.W. Opzoomer, R. O’Sullivan, F.C. Rodriguez, J. Sufi, P. Vlckova, C. Nattress, X. Qin, J. Claus, D. Hochhauser, S. Krishnaswamy, C.J. Tape
Cell (2023)Plastic Persisters: Revival Stem Cells in Colorectal Cancer
C.J. Tape
Trends in Cancer (2023)Activation Priming and Cytokine Polyfunctionality Modulate the Enhanced Functionality of Low-Affinity CD19 CAR T Cells
I.M. Michelozzi, E. Gomez-Castaneda, R.V.C. Pohle, F.C. Rodriguez, J. Sufi, P. Puigdevall-Costa, M. Subramaniyam, E. Kirtsios, A. Eddaoudi, S.W. Wu, A. Guvenel, J. Fisher, S. Ghorashian, M. Pule, C.J. Tape, S. Castellano, P.J. Amrolia, A. Giustacchini
Blood Advances (2022)High-Dimensional Functional Phenotyping of Preclinical Human CAR T Cells Using Mass Cytometry
I.M. Michelozzi, J. Sufi, T.A. Adejumo, P.J. Amrolia, C.J. Tape, A. Giustacchini
STAR Protocols (2022)Multiplexed Single-Cell Analysis of Organoid Signaling Networks
J. Sufi*, X. Qin*, F.C. Rodriguez, Y.J. Bu, P. Vlckova, M.R. Zapatero, M. Nitz, C.J. Tape
Nature Protocols (2021)Intra- and Intercellular Signaling Pathways Associated with Drug-induced Cardiac Pathophysiology
F. Guo, A. Hall, C.J. Tape, S. Ling, A. Pointon
Trends in Pharmacological Sciences (2021)Deciphering Organoids: High-Dimensional Analysis of Biomimetic Cultures
X. Qin, C.J. Tape
Trends in Biotechnology (2021)Cell-Type Specific Signaling Networks in Heterocellular Organoids
X. Qin, J. Sufi*, P. Vlckova*, P. Kyriakidou*, S.E. Acton, V.S.W. Li, M. Nitz, C.J. Tape
Nature Methods (2020)Cross-talk with Lung Epithelial Cells Regulates Sfrp2-mediated Latency in Breast Cancer Dissemination
M. Montagner, R. Bhome, S. Hooper, P. Chakravarty, X. Qin, J. Sufi, A. Bhargava, C.D.H. Ratcliffe, Y. Naito, A. Pocaterra, C.J. Tape, E. Sahai
Nature Cell Biology (2020)Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
J.L. Orgaz, E. Crosas-Molist, A. Sadok, A. Perdrix-Rosell, O. Maiques, I. Rodriguez-Hernandez, J. Monger, S. Mele, M. Georgouli, V. Bridgeman, P. Karagiannis, R. Lee, P. Pandya, L. Boehme, F. Wallberg, C.J. Tape, S.N. Karagiannis, I. Malanchi, V. Sanz-Moreno
Cancer Cell (2020)Fibroblastic Reticular Cells Control Conduit Matrix Deposition during Lymph Node Expansion
V.G. Martinez, V. Pankova, L. Krasny, T. Singh, S. Makris, I.J. White, A.C. Benjamin, S. Dertschnig, H.L. Horsnell, J. Kriston-Vizi, J.J. Burden, P.H. Huang, C.J. Tape, S.E. Acton
Cell Reports (2019)Cell-Specific Labelling For Analysing Bidirectional Signalling by Mass Spectrometry
C.J. Tape & C. Jørgensen
Kinase Signaling Networks, Methods in Mol. Bio. (2017)The Heterocellular Emergence of Colorectal Cancer
C.J. Tape
Trends in Cancer (2017)Proteomics Profiling of Interactome Dynamics by Colocalisation Analysis (COLA)
F.K. Mardakheh, H.Z. Sailem, S. Kümper, C.J. Tape, R.R. McCully, A. Paul, S. Anjomani-Virmouni, C. Jørgensen, G. Poulogiannis, C.J. Marshall, C. Bakal
Molecular BioSystems. (2016)Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation
C.J. Tape, S. Ling, M. Dimitriadi, K.M. McMahon, J.D. Worboys, H.S. Leong, I.C. Norrie, C.J. Miller, G. Poulogiannis, D.A. Lauffenburger, C. Jørgensen
Cell (2016)
Systems Biology Analysis of Heterocellular Signaling
C.J. Tape
Trends in Biotechnology (2016)Microenvironmental Heterogeneity Parallels Breast Cancer Progression: A Histology-Genomic Integration Analysis
R. Natrajan, H. Sailem , F.K. Mardakheh, M.A. Garcia, C.J. Tape, M. Dowsett, C. Bakal, Y. Yuan
PLOS Medicine (2016)Antibody-based exosite inhibitors of ADAMTS-5 (Aggrecanase-2)
S. Santamaria, K. Yamamoto, K.A. Botkjaer, C.J. Tape, M.R. Dyson, J. McCafferty, G. Murphy, H. Nagase
Biochemical Journal (2015)Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells
F. Caiazza, P.M. McGowan, M. Mullooly, A. Murray, N. Synnott, N. O'Donovan, L. Flanagan, C.J. Tape, G. Murphy, J. Crown, M.J. Duffy
British Journal of Cancer (2015)Reproducible Automated Phosphopeptide Enrichment using Magnetic TiO2 and Ti-IMAC
C.J. Tape, J.D. Worboys, J. Sinclair, R. Gourlay, J. Vogt, K.M. McMahon, M. Trost, D.A. Lauffenburger, D.J. Lamont, C. Jørgensen
Analytical Chemistry (2014)Cell-Specific Labeling Enzymes For Analysis of Cell-Cell Communication in Continuous Co-Culture
C.J. Tape, I.C. Norrie, J.D. Worboys, L. Lim, D.A. Lauffenburger, C. Jørgensen
Molecular & Cellular Proteomics (2014)Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model in vivo
F.M. Richards*, C.J. Tape*, D.I. Jodrell, G. Murphy
PLOS One (2012)Cross-domain Inhibition of TACE Ectodomain
C.J. Tape, S.H. Willems, S.L. Dombernowsky, P.L. Stanley, M. Fogarasi, W. Ouwehand, J. McCafferty, G. Murphy
PNAS (2011)Thiol Isomerases Negatively Regulate the Cellular Shedding Activity of ADAM17
S.H. Willems, C.J. Tape, P.L. Stanley, N.A. Taylor, I.G. Mills, D.E. Neal, J. McCafferty, G. Murphy
Biochemical Journal (2010)* = Equal Authorship
Patents
C.J. Tape, J. McCafferty, G. Murphy, ‘Anti-TACE Antibody Molecules And Their Uses’, WO2012104581, US-9150659-B2 (2012). USPTO